20 ways to live to 100

Bill Andrews PHD
President &CEO
bandrews@sierrasci.com
ph 775 856 9500 ext 108
http://www.sierrasci.com
Sierra Sciences, LLC
250 S. Rock Blvd. #130
Reno Nevada 89502

Curing Aging

Sierra Sciences, LLC is a company devoted to finding ways to extend our healthspans and lifespans beyond the theoretical maximum of 125 years.

Scientific research has shown that this theoretical maximum is limited because of the length of our telomeres which shorten as we get older. Our reproductive cells don�t experience this shortening, and thus don�t age, because they contain an enzyme called telomerase that re-lengthens the telomeres as they shorten. Sierra Sciences is searching for pharmaceuticals that will induce the production of telomerase in all our cells.

On November 6th, 2007 Sierra Sciences found its first telomerase inducing chemical; called C0057684. This chemical is the first ever discovered that activates the telomerase gene without killing the cells. Efforts are presently underway to learn everything possible about C0057684. But, in addition, C0057684 has provided Sierra Sciences with the first positive control ever for detection of telomerase gene activity in normal human cells. This has served as a very powerful tool for the development of robust high throughput screening assays for finding additional telomerase inducing chemicals. As such, in the last year Sierra Sciences has discovered an additional 62 chemicals that activate the telomerase gene. This now enables the scientists at Sierra Sciences to design better chemicals with increased potency and specificity. Additional screening for even more chemicals is also underway.

News

Cell Senescence

Cell senescence and aging are known to be strongly correlated with the progressive shortening of telomeres at the ends of chromosomes. Telomerase can extend telomeres, but the telomerase gene is genetically down-regulated early in development in nearly all human cells. read more

Telomerase: A Key to Controlling Aging

We believe aging can be controlled by controlling telomere length. Relengthening telomeres may possibly rejuvenate cell function to a healthy pre-senescent state. More ...

CURE AGING!!

Here's how you can help.

Sierra Sciences is seeking individuals passionate about finding the cure for aging to get involved in the company at levels of funding, strategy, and management. (more)

Follow our Progress:

The Search for Telomerase Inducers

As of April 16th, 2009:

We have screened 69,520 Compounds

We have found 119 telomerase inducers

These represent 30 distinct drug families

Most potent compound = 6% of goal

Check back frequently for updates!

We are screening 4,000 compounds per week.

Caution!